1. From the Vascular and Stroke Center, Institute of Cardiovascular Sciences, Manchester Academic Health Sciences Center, University of Manchester, United Kingdom (J.P.G., H.C.P.); Greater Manchester Neurosciences Center, Salford Royal Foundation NHS Trust, United Kingdom (L.D., H.C.P.); and Ninewells Hospital and Medical School, Ninewells, Dundee, United Kingdom (J.P.G.).