Abstract
Background
Both intracranial aneurysms and aneurysmal subarachnoid hemorrhages are medical conditions characterized by high rates of mortality and disability. The research on the role of CD45 in cerebrovascular diseases is controversial, but the role of CD45 in intracranial aneurysms and aneurysmal subarachnoid hemorrhages is unknown. This study employs Mendelian randomization (MR) to rigorously test the causal impact of CD45 on these cerebral conditions.
Methods
We analyzed GWAS summary statistics for CD45 alongside data for both intracranial aneurysm and aneurysmal subarachnoid hemorrhage. Instrumental variables were carefully selected in alignment with MR standards. Our primary analysis method was inverse variance weighted (IVW), augmented by four alternative MR approaches to enrich the analysis. Comprehensive sensitivity tests were conducted to validate the robustness of our findings.
Results
Results from the IVW analysis suggested that a one-standard-deviation increase in CD45 levels is associated with a 19.6% increase in the risk of intracranial aneurysm and a 13.8% increase in the risk of aneurysmal subarachnoid hemorrhage (OR = 1.196, 95% CI: 1.038–1.379, P = 0.0136; OR = 1.138, 95% CI: 1.046–1.237, P = 0.0025 respectively). These results were consistent across additional MR methods. Sensitivity analyses reinforced the reliability of the findings, confirming no significant influence from pleiotropy or other biases.
Conclusion
Our findings substantiate a causal relationship between elevated CD45 levels and increased risks of intracranial aneurysm and aneurysmal subarachnoid hemorrhage. These insights suggest new avenues for therapeutic intervention, although further studies are needed to clarify the mechanisms involved.