Studies on the Control of Hypertension by Hyphex

Author:

MORROW JOHN D.1,SCHROEDER HENRY A.1,PERRY H. MITCHELL1

Affiliation:

1. From the Hypertension Division, Department of Internal Medicine, Washington University School of Medicine, and Barnes Hospital, St. Louis, Mo.

Abstract

Although effective in maintaining relatively normal levels of blood pressure in hypertensive patients and retarding some of the serious and fatal secondary consequences of the disease, hexamethonium ion and 1-hydrazinophthalazine can cause severe immediate and late reactions. The latter drug has produced collagen diseases of varying degrees of severity, all of which have regressed on cessation of medication, in 14 of 253 patients. The combination has given rise to fatal interstitial pneumonia in 5 of 89 in malignant stages of hypertension. Less serious side effects of each agent are also discussed.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference7 articles.

1. Studies on the Control of Hypertension by Hyphex

2. 2PERRY H. M. JR. MORROW J. D. AND SCHROEDER H. A.: Studies on the control of hypertension by Hyphex. III. Chemical and pharmacological observations. (To be published.)

3. Acute diffuse interstitial fibrosis of the Iungs;HAMMAN L.;Bull. Johns Hopkins Hosp.,1944

4. The methonium compounds;PATON W. D.;Pharmacol. Rev.,1952

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