Inhibition of Plasmin Activity by Tranexamic Acid Does Not Influence Inflammatory Pathways During Human Endotoxemia

Author:

Renckens Rosemarijn1,Weijer Sebastiaan1,de Vos Alex F.1,Pater Jennie M.1,Meijers Joost C.1,Hack C. Erik1,Levi Marcel1,van der Poll Tom1

Affiliation:

1. From the Laboratory of Experimental Internal Medicine (R.R., S.W., A.F.d.V., J.M.P., T.v.d.P.), Departments of Vascular Medicine (J.C.M., M.L.) and Infectious Diseases (T.v.d.P.), Tropical Medicine & AIDS, Academic Medical Center, University of Amsterdam; and the Sanquin Research at the CLB (C.E.H.), Amsterdam, The Netherlands.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Reference39 articles.

1. van der Poll T van Deventer SJH. Endotoxemia in healthy subjects as a human model of inflammation. In: Cohen MJ Marshall J. eds. The Immune Response in the Critically Ill. New York New York: Springer-Verlag; 1999.

2. Suffredini AF O’Grady NP. Pathophysiology responses to endotoxin in humans. In: Morrison DC Opal S Vogel S eds. Endotoxin in Health and Disease. New York: Marcel Dekker; 1999.

3. Promotion and Subsequent Inhibition of Plasminogen Activation after Administration of Intravenous Endotoxin to Normal Subjects

4. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

5. Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia

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