1. From the Institute for Clinical Evaluative Sciences and University Health Network (D.S.L.), University of Toronto, Canada; the National Heart, Lung, and Blood Institute’s Framingham Heart Study (J.C.E., S.J.R., C.S.F., T.J.W., E.J.B., R.B.D., R.S.V.), Framingham, Mass; the Endocrine-Metabolic Laboratory (I.A.), Department of Medical and Surgical Sciences, University of Padova, Italy; the Department of Medicine (P.W.W.), Medical University of South Carolina, Charleston; the Mathematics Department (R...