1. From the Institute of Clinical Pharmacology (J.T., K.Heu., K.Heg., S.H., J.B., J.J.), Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery (D.M., C.B., M.S.), and Institute of Sports Medicine (S.H., U.T.), Hannover Medical School, Hannover, Germany; Division of Clinical Pharmacology (A.D.), Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.