Affiliation:
1. Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden
2. Department of Clinical Physiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden
Abstract
Background
Biomarker activation in atrial fibrillation (
AF
) has been widely studied, but the immediate effect of
AF
initiation remains unclear. We studied the effect of
AF
initiation on 2 cardiac biomarkers: the N‐terminal fragment of the proB‐type natriuretic peptide (
NT
‐pro
BNP
), the midregional fragment of the N‐terminal of pro‐atrial natriuretic peptide (
MR
‐pro
ANP
), and 2 extracardiac biomarkers—the copeptin and the midregional portion of proadrenomedullin (
MR
‐pro
ADM
).
Methods and Results
This was a randomized controlled study, including 45 patients with
AF
who had been referred for radiofrequency ablation to the University Hospital, Linköping, Sweden, between February 2012 and April 2014. Freedom from
AF
during the 4 days prior to radiofrequency ablation was confirmed by transtelephonic
ECG
s. Biomarkers were collected from the femoral vein (fv), coronary sinus (
CS
), and left atrium (
LA
) prior to
AF
initiation (baseline) and 30 minutes later. The
MR
‐pro
ANP
and
NT
‐pro
BNP
concentrations increased in the intervention group compared with the control group 30 minutes after the initiation of
AF
(
MR
‐pro
ANP
:
P
fv
<0.001,
P
CS
<0.001,
P
LA
<0.001;
NT
‐pro
BNP
:
P
LA
<0.001). Copeptin levels in patients without ischemic heart disease were decreased after the initiation of
AF
(
P
fv
=0.003,
P
CS
=0.015,
P
LA
=0.011).
Conclusions
AF
is a strong stimulus that results in immediate activation of different biomarkers.
Clinical Trial Registration
URL
:
http://www.clinicaltrials.gov
. Unique identifier:
NCT
01553045.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
10 articles.
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