Spectrum of Non-Obstructive Coronary Artery Disease and Its Relationship with Atrial Fibrillation-Reference-Cited by-同舟云学术

Spectrum of Non-Obstructive Coronary Artery Disease and Its Relationship with Atrial Fibrillation

Published:2024-08-21 Issue:16 Volume:13 Page:4921
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Oancea Alexandru-Florinel¹²^ORCID,Morariu Paula¹²,Buburuz Ana¹²,Miftode Ionela-Larisa³⁴^ORCID,Miftode Radu¹²,Mitu Ovidiu¹²^ORCID,Jigoranu Alexandru¹²^ORCID,Floria Diana-Elena¹²,Timpau Amalia¹²,Vata Andrei³⁴^ORCID,Plesca Claudia³⁴,Botnariu Gina²⁵,Burlacu Alexandru¹⁶^ORCID,Scripcariu Dragos-Viorel¹⁷,Raluca Mitea⁸,Cuciureanu Magdalena⁹^ORCID,Tanase Daniela¹²^ORCID,Costache-Enache Irina¹²,Floria Mariana¹²^ORCID

Affiliation:

1. Department of Internal Medicine I, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania

2. Saint Spiridon Emergency Hospital, 700115 Iasi, Romania

3. Department of Internal Medicine II, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania

4. St Parascheva Clinical Hospital of Infectious Diseases, 700116 Iasi, Romania

5. Unit of Diabetes, Nutrition and Metabolic Diseases, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania

6. Cardiovascular Disease Institute, 700503 Iasi, Romania

7. Regional Institute of Oncology, 700483 Iasi, Romania

8. Faculty of Medicine Victor Papilian, University of Lucian Blaga, 550169 Sibiu, Romania

9. Department of Pharmacology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania

Abstract

This article aims to analyze the relationship between non-obstructive coronary artery disease (NOCAD) and atrial fibrillation (AF), exploring the underlying pathophysiological mechanisms and implications for clinical management. NOCAD and AF are prevalent cardiovascular conditions that often coexist, yet their interrelation is not well understood. NOCAD can lead to ischemic necrosis of cardiomyocytes and their replacement with fibrous tissue, sustaining focal ectopic activity in atrial myocardium. Atrial fibrillation, on the other hand, the most common sustained cardiac arrhythmia, is able to accelerate atherosclerosis and increase oxygen consumption in the myocardium, creating a mismatch between supply and demand, and thus promoting the development or worsening of coronary ischemia. Therefore, NOCAD and AF seem to be a complex interplay with one begets another.

Publisher

MDPI AG

Link

https://www.mdpi.com/2077-0383/13/16/4921/pdf

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