Effect of Body Size, Ponderosity, and Blood Pressure on Left Ventricular Growth in Children and Young Adults in the Bogalusa Heart Study

Abstract

BackgroundThe measurement of left ventricular mass (LVM) is important because individuals with increased LVM are at increased risk for cardiovascular diseases, including myocardial infarction and congestive heart failure. There are limited longitudinal data on the acquisition of LVM in children and young adults and the relative importance of sex, growth, excess body weight, and blood pressure (BP) on change in LVM.Methods and ResultsThe study cohort consisted of a cross section of 160 healthy children and young adults 9 to 22 years of age at first exam in the biracial community of Bogalusa, La. All had stable BP levels recorded over a 2- to 3-year period. Repeated examinations were performed 4 to 5 years apart. At each exam, 6 BPs were obtained with a mercury sphygmomanometer by trained examiners. The mean of the observations was used, with the fourth Korotkoff phase serving as the measure of diastolic BP. Anthropometric data, including height (HT), weight (WT), and triceps skin fold thickness (TSF), were also obtained, and M-mode echocardiograms were performed. Ponderal index (PI=WT/HT3) was used as a measure of weight-for-height. Tracking of HT (r=.68 to .76), WT (r=.73 to .82), PI (r=.77 to .89), TSF (r=.70 to .80), BP (r=.47 to .60), and LVM (r=.40 to .70) was strong in both sexes (P<.0001). LVM indexed for linear growth (LVM/HT2.7) tracked in females (r=.56,P<.0001) but not in males. In univariate cross-sectional analyses, LVM/HT2.7correlated with WT, PI, and TSF in both sexes (r=.21 to .60,P<.05) and with systolic BP (SBP) in females (r=.23,P<.05). WT was the only independent correlate of LVM/HT2.7in both sexes in multivariate cross-sectional analysis in a model containing age, SBP, WT, and TSF as independent variables (r2=.08 to .28,P<.02). In longitudinal univariate analyses, initial measurements of WT, PI, and TSF predicted final LVM/HT2.7in both sexes (r=.28 to .56,P<.01), and SBP was significant for females (r=.27,P<.05). In multivariate analyses, initial WT was associated with final LVM and LVM/HT2.7in both sexes (r2=.27 to .54,P<.01). Finally, baseline LVM correlated with final SBP in both sexes (r=.21 to .27,P<.05), and initial LVM/HT2.7correlated with final SBP in females (r=.26,P<.05) with a trend for males (r=.17).ConclusionsThese data indicate that linear growth is the major determinant of cardiac growth in children and that excess weight may lead to the acquisition of LVM beyond that expected from normal growth. Increased mass may also precede the development of increased BP. The development of obesity may therefore be a significant, and possibly modifiable, risk factor for developing left ventricular hypertrophy and hypertension, risk factors for cardiovascular morbidity and mortality.