Affiliation:
1. From the Cardiovascular Neurophysiology Laboratory, Cardiovascular Division, Department of Internal Medicine (K.N., P.J.H.v.d.B., R.L.C., V.K.S.) and the Department of Neurology (M.E.D.), University of Iowa College of Medicine, Iowa City.
Abstract
Background
—Obese humans are reported to have increased muscle sympathetic nerve activity (MSNA). Obstructive sleep apnea (OSA) may also be accompanied by increased MSNA. Because there is a high prevalence of OSA in obese humans, it is possible that high MSNA reported in obese subjects may in fact reflect the presence of OSA in these subjects. We tested the hypothesis that obesity, per se, in the absence of OSA, is not accompanied by increased MSNA.
Methods and Results
—We measured MSNA in 25 healthy normal-weight subjects and 30 healthy sedentary obese subjects. All subjects were screened by history and examination to exclude subjects with OSA or hypertension. OSA was further excluded by overnight polysomnographic studies. Despite careful screening, polysomnography revealed that 1 of 25 normal-weight subjects and 9 of 30 obese subjects had occult OSA (
P
=0.015). MSNA was similar in normal-weight subjects (41±3 bursts per 100 heartbeats) and obese subjects without sleep apnea (42±3 bursts per 100 heartbeats,
P
=0.99). MSNA in the 9 obese subjects with occult OSA was 61±8 bursts per 100 heartbeats, which was higher than MSNA in normal-weight subjects without sleep apnea (
P
=0.02) and higher than MSNA in obese subjects without sleep apnea (
P
=0.02).
Conclusions
—Obesity alone, in the absence of OSA, is not accompanied by increased sympathetic activity to muscle blood vessels.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Cited by
427 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献