Affiliation:
1. SMUR and the Department of Anesthesiology and Critical Care, Lariboisie`re University Hospital (P.P., F.A., M.G., D.P.); Biophysic Laboratory, Fernand Widal Hospital (E.V.); SMUR, Saint Denis Hospital (SAMU 93) (B.H.); SMUR and the Department of Anesthesiology and Critical Care, Avicenne University Hospital (SAMU 93) (P.M., C.P.); SMUR and the Department of Anesthesiology and Critical Care, Henri Mondor University Hospital (SAMU 94) (Y.L., J.-P.C.); SMUR and the Department of Anesthesiology and...
Abstract
Background
We compared short-term prognosis of active compression-decompression (ACD) and standard (STD) cardiopulmonary resuscitation (CPR) in out-of-hospital cardiac arrests.
Methods and Results
We randomized advanced cardiac life support (ACLS) with ACD ACLS CPR on odd days and STD ACLS CPR on even days. We measured the rates of return of spontaneous circulation (ROSC), survival at 1 hour (H
1
), at 24 hours (H
24
), and at 1 month (D
30
); hospital discharge (HD); neurological outcome; and complications. Mean times from collapse to basic cardiac life support CPR was 9 minutes and from collapse to ACLS CPR was 21 minutes. Compared with the STD ACLS patients (n=258), ACD ACLS patients (n=254) had higher survival rates (ROSC, 44.9% versus 29.8%,
P
=.0004; H
1
, 36.6% versus 24.8%,
P
=.003; H
24
, 26% versus 13.6%,
P
=.002; HD without neurological impairment, 5.5% versus 1.9%,
P
=.03) and a trend for improvement in neurological outcome at D
30
(Glasgow-Pittsburgh Outcome Categories=1.6±0.8 versus 2.3±1.1,
P
=.09). Sternal dislodgments (2.9% versus 0.4%,
P
=.03) and hemoptysis (5.4% versus 1.3%,
P
=.01) were more frequent in the ACD ACLS group.
Conclusions
Despite long time intervals, ACD significantly improved short-term survival rates in out-of-hospital cardiac arrests compared with STD CPR.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Cited by
117 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献