1. From the Faculty of Life Sciences (T.E.K., J.J., W.L., A.H.W., X.W.) and Faculty of Medical and Human Sciences (M.Z., S.P., D.O., L.N., E.J.C.), University of Manchester, United Kingdom; and Aab Cardiovascular Research Institute (J.-i.A.), University of Rochester School of Medicine and Dentistry, NY.