Bone and Extracellular Signal-Related Kinase 5 (ERK5)-Reference-Cited by-同舟云学术

Bone and Extracellular Signal-Related Kinase 5 (ERK5)

Published:2024-05-04 Issue:5 Volume:14 Page:556
ISSN:2218-273X
Container-title:Biomolecules
language:en
Short-container-title:Biomolecules

Author:

Wen Lei¹²³^ORCID,Liu Zirui¹²,Zhou Libo¹²,Liu Zhongcheng¹²,Li Qingda¹²,Geng Bin¹²,Xia Yayi¹²

Affiliation:

1. Department of Orthopedics, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, China

2. Orthopedic Clinical Medical Research Center and Intelligent Orthopedic Industry Technology Center of Gansu Province, Lanzhou 730030, China

3. Department of Orthopedics and Trauma Surgery, Affiliated Hospital of Yunnan University, Kunming 650032, China

Abstract

Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recently identified member of the mitogen-activated protein kinase (MAPK) family, plays a critical role in the pathogenesis and progression of various diseases, especially neoplasms. Recent studies have highlighted ERK5’s significant role in both bone development and bone-associated pathologies. This review offers a detailed examination of the latest research on ERK5 in different tissues and diseases, with a particular focus on its implications for bone health. It also examines therapeutic strategies and future research avenues targeting ERK5.

Funder

National Natural Science Foundation of China

Lanzhou Science and Technology Plan Program

Natural Science Foundation of Gansu Province

Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital

Publisher

MDPI AG

Link

https://www.mdpi.com/2218-273X/14/5/556/pdf

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