1. From the Departments of Biomedical Sciences (K.H.S., J.F.G., T.J., E.A.B., T.Z., K.E.B., X.Z.S.), Pathology (K.E.B., X.Z.S.), and Neurology (P.S., Y.L.), Cedars-Sinai Medical Center, Los Angeles, CA; and Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (D.G.H).