Leveraging Spaceflight to Advance Cardiovascular Research on Earth-Reference-Cited by-同舟云学术

Leveraging Spaceflight to Advance Cardiovascular Research on Earth

Published:2022-03-18 Issue:6 Volume:130 Page:942-957
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circ Res

Author:

Scott Jessica M.¹²^ORCID,Stoudemire Jana³^ORCID,Dolan Lianne⁴,Downs Meghan⁵

Affiliation:

1. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY (J.M.S.).

2. Weill Cornell Medical College, New York, NY (J.M.S.).

3. Axiom Space, Houston, TX (J.S.).

4. Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada (L.D.).

5. NASA Johnson Space Center, Houston, TX (M.D.).

Abstract

The direct (eg, radiation, microgravity) and indirect (eg, lifestyle perturbations) effects of spaceflight extend across multiple systems resulting in whole-organism cardiovascular deconditioning. For over 50 years, National Aeronautics and Space Administration has continually enhanced a countermeasures program designed to characterize and offset the adverse cardiovascular consequences of spaceflight. In this review, we provide a historical overview of research evaluating the effects of spaceflight on cardiovascular health in astronauts and outline mechanisms underpinning spaceflight-related cardiovascular alterations. We also discuss how spaceflight could be leveraged for aging, industry, and model systems such as human induced pluripotent stem cell–derived cardiomyocytes, organoid, and organ-on-a-chip technologies. Finally, we outline the increasing opportunities for scientists and clinicians to engage in cardiovascular research in space and on Earth.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

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