The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight-Reference-Cited by-同舟云学术

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

Published:2019-04-12 Issue:6436 Volume:364 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Garrett-Bakelman Francine E.¹²,Darshi Manjula³^ORCID,Green Stefan J.⁴^ORCID,Gur Ruben C.⁵,Lin Ling⁶^ORCID,Macias Brandon R.⁷^ORCID,McKenna Miles J.⁸^ORCID,Meydan Cem¹⁹^ORCID,Mishra Tejaswini⁶^ORCID,Nasrini Jad⁵^ORCID,Piening Brian D.⁶^ORCID,Rizzardi Lindsay F.¹⁰^ORCID,Sharma Kumar³^ORCID,Siamwala Jamila H.¹¹^ORCID,Taylor Lynn⁸^ORCID,Vitaterna Martha Hotz¹²^ORCID,Afkarian Maryam¹³^ORCID,Afshinnekoo Ebrahim¹⁹^ORCID,Ahadi Sara⁶^ORCID,Ambati Aditya⁶^ORCID,Arya Maneesh⁷^ORCID,Bezdan Daniela¹⁹^ORCID,Callahan Colin M.¹⁰^ORCID,Chen Songjie⁶^ORCID,Choi Augustine M. K.¹,Chlipala George E.⁴^ORCID,Contrepois Kévin⁶^ORCID,Covington Marisa¹⁴^ORCID,Crucian Brian E.¹⁴,De Vivo Immaculata¹⁵^ORCID,Dinges David F.⁵^ORCID,Ebert Douglas J.⁷^ORCID,Feinberg Jason I.¹⁰,Gandara Jorge A.¹^ORCID,George Kerry A.⁷^ORCID,Goutsias John¹⁰^ORCID,Grills George S.¹^ORCID,Hargens Alan R.¹¹^ORCID,Heer Martina¹⁶^ORCID,Hillary Ryan P.⁶^ORCID,Hoofnagle Andrew N.¹⁷^ORCID,Hook Vivian Y. H.¹¹,Jenkinson Garrett¹⁰^ORCID,Jiang Peng¹²^ORCID,Keshavarzian Ali¹⁸^ORCID,Laurie Steven S.⁷^ORCID,Lee-McMullen Brittany⁶^ORCID,Lumpkins Sarah B.¹⁹,MacKay Matthew¹,Maienschein-Cline Mark G.⁴^ORCID,Melnick Ari M.¹^ORCID,Moore Tyler M.⁵^ORCID,Nakahira Kiichi¹,Patel Hemal H.¹¹^ORCID,Pietrzyk Robert⁷,Rao Varsha⁶^ORCID,Saito Rintaro¹¹,Salins Denis N.⁶^ORCID,Schilling Jan M.¹¹^ORCID,Sears Dorothy D.¹¹^ORCID,Sheridan Caroline K.¹^ORCID,Stenger Michael B.¹⁴,Tryggvadottir Rakel¹⁰^ORCID,Urban Alexander E.⁶^ORCID,Vaisar Tomas¹⁷^ORCID,Van Espen Benjamin¹¹^ORCID,Zhang Jing⁶,Ziegler Michael G.¹¹,Zwart Sara R.²⁰,Charles John B.¹⁴,Kundrot Craig E.²¹^ORCID,Scott Graham B. I.²²^ORCID,Bailey Susan M.⁸^ORCID,Basner Mathias⁵^ORCID,Feinberg Andrew P.¹⁰^ORCID,Lee Stuart M. C.⁷^ORCID,Mason Christopher E.¹⁹²³²⁴^ORCID,Mignot Emmanuel⁶^ORCID,Rana Brinda K.¹¹^ORCID,Smith Scott M.¹⁴,Snyder Michael P.⁶,Turek Fred W.¹²^ORCID

Affiliation:

1. Weill Cornell Medicine, New York, NY, USA.

2. University of Virginia School of Medicine, Charlottesville, VA, USA.

3. Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.

4. University of Illinois at Chicago, Chicago, IL, USA.

5. University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

6. Stanford University School of Medicine, Palo Alto, CA, USA.

7. KBRwyle, Houston, TX, USA.

8. Colorado State University, Fort Collins, CO, USA.

9. The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.

10. Johns Hopkins University, Baltimore, MD, USA.

11. University of California, San Diego, La Jolla, CA, USA.

12. Northwestern University, Evanston, IL, USA.

13. University of California, Davis, Davis, CA, USA.

14. National Aeronautics and Space Administration (NASA), Houston, TX, USA.

15. Harvard T.H. Chan School of Public Health, Boston, MA, USA.

16. University of Bonn, Bonn, Germany.

17. University of Washington, Seattle, WA, USA.

18. Rush University Medical Center, Chicago, IL, USA.

19. MEI Technologies, Houston, TX, USA.

20. University of Texas Medical Branch, Galveston, TX, USA.

21. Space Life and Physical Sciences Division, NASA Headquarters, Washington, DC, USA.

22. National Space Biomedical Research Institute, Baylor College of Medicine, Houston, TX, USA.

23. The Feil Family Brain and Mind Research Institute, New York, NY, USA.

24. The WorldQuant Initiative for Quantitative Prediction, New York, NY, USA.

Abstract

What to expect after a year in space Space is the final frontier for understanding how extreme environments affect human physiology. Following twin astronauts, one of which spent a year-long mission on the International Space Station, Garrett-Bakelman et al. examined molecular and physiological traits that may be affected by time in space (see the Perspective by Löbrich and Jeggo). Sequencing the components of whole blood revealed that the length of telomeres, which is important to maintain in dividing cells and may be related to human aging, changed substantially during space flight and again upon return to Earth. Coupled with changes in DNA methylation in immune cells and cardiovascular and cognitive effects, this study provides a basis to assess the hazards of long-term space habitation. Science , this issue p. eaau8650 ; see also p. 127

Funder

National Science Foundation

National Institutes of Health

National Institute of Diabetes and Digestive and Kidney Diseases

National Aeronautics and Space Administration

DLR Space program

WorldQuant Foundation

Starr Foundation

Pershing Square Foundation

NASA Astrobiology Institute

NIDDK

Publisher