New and TALENted Genome Engineering Toolbox-Reference-Cited by-同舟云学术

New and TALENted Genome Engineering Toolbox

Published:2013-08-16 Issue:5 Volume:113 Page:571-587
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circ Res

Author:

Campbell Jarryd M.¹,Hartjes Katherine A.¹,Nelson Timothy J.¹,Xu Xiaolei¹,Ekker Stephen C.¹

Affiliation:

1. From the Center for Translational Science Activities (J.M.C., S.C.E.), Center for Regenerative Medicine (K.A.H., T.J.N.), Department of Molecular Pharmacology and Experimental Therapeutics (K.A.H., T.J.N.), Division of General Internal Medicine (T.J.N.), Transplant Center (T.J.N.), Division of Cardiovascular Diseases (X.X.), and Department of Biochemistry and Molecular Biology (X.X., S.C.E.), Mayo Clinic, Rochester, MN.

Abstract

Recent advances in the burgeoning field of genome engineering are accelerating the realization of personalized therapeutics for cardiovascular disease. In the postgenomic era, sequence-specific gene-editing tools enable the functional analysis of genetic alterations implicated in disease. In partnership with high-throughput model systems, efficient gene manipulation provides an increasingly powerful toolkit to study phenotypes associated with patient-specific genetic defects. Herein, this review emphasizes the latest developments in genome engineering and how applications within the field are transforming our understanding of personalized medicine with an emphasis on cardiovascular diseases.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.113.301765

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