Affiliation:
1. From the Unit of Cardiac Physiology, Division of Cardiovascular Sciences, University of Manchester, United Kingdom.
Abstract
Normal cardiac function requires that intracellular Ca
2+
concentration be reduced to low levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often associated with impaired cardiac relaxation. Little, however, is known about how diastolic intracellular Ca
2+
concentration is regulated. This article first discusses the reasons for this ignorance before reviewing the basic mechanisms that control diastolic intracellular Ca
2+
concentration. It then considers how the control of systolic and diastolic intracellular Ca
2+
concentration is intimately connected. Finally, it discusses the changes that occur in heart failure and how these may result in heart failure with preserved versus reduced ejection fraction.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Cited by
88 articles.
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