1. From the Division of Endocrinology & Metabolism and Cardiovascular Research Center (D.T.B., S.S., M.E.H., A.W., N.F., C.C.H.), Department of Chemistry (J.J.C., T.L.M.), Department of Biochemistry & Molecular Genetics (M.D.D.), and Department of Pharmacology (K.W.K., K.R.L., C.C.H.), University of Virginia, Charlottesville, Va; Division of Cardiology (P.S.T.), Stanford University, Palo Alto, Calif.