1. From the Departments of Neurology (P.I., K.N., L.S., M.K., P.J.L.), Surgery (E.S.), Pathology (M.-L.K.-L.), and Radiology (O.S.), Helsinki University Central Hospital; the Neuroscience Program (P.I., K.N., J.S., P.J.L.), Biomedicum Helsinki; South Karelia Central Hospital (E.S.), Lappeenranta; the Department of Public Health (S.S.), University of Helsinki; CSC - Scientific Computing Ltd (J.T.), Espoo; and Wihuri Research Institute (P.T.K.), Helsinki, Finland.