Affiliation:
1. Department of Biomedical Sciences University of Antwerp Belgium
2. VIB‐UGent Center for Inflammation Research Belgium
3. Department of Biomedical Molecular Biology Ghent University Belgium
Abstract
Unprotected iron can rust due to oxygen exposure. Similarly, in our body, oxidative stress can kill cells in an iron‐dependent manner, which can give rise to devastating diseases. This type of cell death is referred to as ferroptosis. Generally, ferroptosis is defined as an iron‐catalyzed form of regulated necrosis that occurs through excessive peroxidation of polyunsaturated fatty acids within cellular membranes. This review summarizes how ferroptosis is executed by a rather primitive biochemical process, under tight regulation of lipid, iron, and redox metabolic processes. An overview is given of major classes of ferroptosis inducers and inhibitors, and how to detect ferroptosis. Finally, its detrimental role in disease is briefly discussed.
Funder
Stichting Tegen Kanker
Fondation Charcot
VLIRUOS
Fonds Wetenschappelijk Onderzoek
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
3 articles.
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