CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated Receptors-Reference-Cited by-同舟云学术

CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated Receptors

Published:2000-05-23 Issue:20 Volume:101 Page:2411-2417
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

Chinetti Giulia¹,Gbaguidi Franck G.¹,Griglio Sabine¹,Mallat Ziad¹,Antonucci Micheline¹,Poulain Philippe¹,Chapman John¹,Fruchart Jean-Charles¹,Tedgui Alain¹,Najib-Fruchart Jamila¹,Staels Bart¹

Affiliation:

1. From the U.325 INSERM, Département d’Athérosclerose, Institut Pasteur de Lille, and the Faculté de Pharmacie, Université de Lille II (G.C., F.G.G., P.P., J.-C.F., J.N.-F., B.S.), and U.321 INSERM, Hôpital de la Pitié (S.G., M.A., J.C.), and U.141 INSERM, Hôpital Lariboisière (Z.M., A.T.), Paris, France. The first 2 authors contributed equally to this work.

Abstract

Background —The scavenger receptors are cell-surface receptors for native and modified lipoproteins that play a critical role in the accumulation of lipids by macrophages. CLA-1/SR-BI binds HDL with high affinity and is involved in the cholesterol reverse-transport pathway. Peroxisome proliferator–activated receptors (PPARs) are transcription factors regulating the expression of genes implicated in lipid metabolism, cellular differentiation, and inflammation. Here, we investigated the expression of CLA-1/SR-BI in macrophages and its regulation by PPARs. Methods and Results —CLA-1 is undetectable in human monocytes and is induced upon differentiation into macrophages. Immunohistological analysis on human atherosclerotic lesions showed high expression of CLA-1 in macrophages of the lipid core colocalizing with PPARα and PPARγ staining. Activation of PPARα and PPARγ resulted in the induction of CLA-1 protein expression in monocytes and in differentiated macrophages. Finally, SR-BI expression is increased in atherosclerotic lesions of apoE-null mice treated with either PPARγ or PPARα ligands. Conclusions —Our data demonstrate that CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and induced by PPAR activation, identifying a potential role for PPARs in cholesterol homeostasis in atherosclerotic lesion macrophages.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.101.20.2411

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