1. From the Department of Clinical Pharmacology (B.A., A.Z., S.V., D.B., P.S., A.H., S.T.), International Centre for Circulatory Health, National Heart and Lung Division, Faculty of Medicine, Imperial College, London, England; the Department of Chemical Engineering (Y.X.), Imperial College, London, England; and the Department of Molecular and Cellular Therapeutics and the RCSI Research Institute (A.S.), Royal College of Surgeon’s in Ireland, Dublin, Ireland.