Affiliation:
1. Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-AKITA, Japan.
Abstract
An in vivo technique was developed for measuring the absolute myocardial blood flow with H215O and dynamic positron-emission tomography. This technique was based on a new model involving the concept of the tissue fraction, which was defined as the fraction of the tissue mass in the volume of the region of interest. The myocardium was imaged dynamically by positron-emission tomography, starting at the time of intravenous bolus injection of H215O. The arterial input function was measured continuously with a beta-ray detector. A separate image after C15O inhalation was also obtained for correction of the H215O radioactivity in the blood. The absolute myocardial blood flow and the tissue fraction were calculated for 15 subjects with a kinetic technique under region-of-interest analysis. These results seem consistent with their coronary angiographic findings. The mean value of the measured absolute myocardial blood flows in normal subjects was 0.95 +/- 0.09 ml/min/g. This technique detected a diffuse decrease of myocardial blood flow in patients with triple-vessel disease.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine
Reference30 articles.
1. Measurement of regional tissue and blood radiotracer concentrations from serial tomographic images of the heart;Henze E;J Nucl Med,1983
2. Quantification of regional myocardial blood flow in vivo with H215O.
3. Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: An assessment of potential and problems;Huang SC;J Nucl Med,1985
Cited by
304 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献