Increasing the natural resistance and survival of minks in case of unfavorable course of Aleutian disease-Reference-Cited by-同舟云学术

Increasing the natural resistance and survival of minks in case of unfavorable course of Aleutian disease

Published:2019-11-27 Issue:6 Volume:2019 Page:14-19
ISSN:2500-4379
Container-title:Russian veterinary journal
language:en
Short-container-title:

Author:

Ростроса Полина¹,Rostrosa Polina²,Санин Александр³,Sanin Aleksandr⁴,Наровлянский Александр³,Narovlyanskiy Aleksandr⁴,Пронин Александр³,Pronin Aleksandr⁴,Кожевникова Татьяна³,Kozhevnikova Tat'yana⁵

Affiliation:

1. АО «Племенной зверосовхоз Салтыковский»

2. Saltykovsky Animal Breeding Farm JSC

3. Федеральное государственное бюджетное учреждение «Национальный исследовательский центр эпидемиологии и микробиологии имени Н.Ф. Гамалеи» Минздрава России

4. The Gamaleya Scientific Research Institute of Epidemiology and Microbiology

5. Gamaleya Scientific Research Institute of Epidemiology and Microbiolo

Abstract

Aleutian mink disease (AMD) caused by parvovirus is a real curse of the industrial mink breeding worldwide. Most minks infected with the AMD virus die, so the symptomatic treatment is aimed to extend the life of diseased minks until the fur maturation. This review contains an analysis of data obtained from the use of Gamavit (GM) and Phosprenyl (PP), which are widely used in practical veterinary medicine, including in fur animals, and have therapeutic efficacy for treating other parvovirus infections of carnivores. Both drugs were administered to minks by mixing with feed at the rate of 0.1 ml per kg of body weight for GM and 0.05 ml per kg of body weight for PP. In efficiency studies of the drugs on healthy animals, it was shown that they had a positive effect on the resistance of animals to adverse impacts (infections, feeding disorders, weaning). GM was most effective for increasing the fertility and number of kits per female, as well as for reducing the alimentary anemia, while PP was effective for increasing the survival rate of kits and contributed to their growth. Both drugs stimulated phagocytosis, increased SBA and SLA. The combined use of PP and GM increased the survival rate of young animals by 7.3% and the number of kits per female by 0.45 animals, as well as increased the number of defect-free skins by 7%. In addition, it eliminated anemia and increased the level of hemoglobin and erythrocytes in minks affected with AMD, although they did not reach the lower limit of the norm. Moreover, the use of PP and GM increased the number of kits per female by 0.7 animals vs. control, while the mortality rate of young animals reduced by 9.8%. Thus, the combined use of GM and PP in minks can increase the main natural resistance indicators (SBA, SLA levels, phagocytosis indicators, the absorption ability of peripheral blood granulocytes, the activity of natural killer cells) and significantly reduce anemia. Furthermore, the combined use of the drugs can increase the survival rate of young animals, the number of kits per female, reduce the live weight decrease in kits and increase the number of defect-free skins.

Publisher

Publishing House Logos Press

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