UTERINE FIBROIDS IMPACT ON FERTILITY AND PREGNANCY OUTCOME

Author:

Doroha Olena1,Iarotskyi Mykola2,Iarotska Iryna3,Semeniuk Liudmyla4,Nikitina Olga5

Affiliation:

1. Shupyk National Medical Academy of Postgraduate Education; State Scientific Institution “Scientific and Practical Center for Preventive and Clinical Medi-cine” of the State Administration of Affairs

2. Academic Medical Center

3. Shupyk National Medical Academy of Postgraduate Education

4. Ukrainian Scientific and Practical Center for Endocrine Surgery, Transportation Endocrine Organ and Tissues Ministry of Health of Ukraine

5. State Scientific Institution “Scientific and Practical Center for Preventive and Clinical Medi-cine” of the State Administration of Affairs

Abstract

The clinical confirmation of the relationship between uterine leiomyoma and female infertility is of interest to scholars. The aim of our research was to study obstetric history and the level of sex hormones in women of reproductive age with leiomyoma. Materials and methods. The main group consisted of 90 women of reproductive age with uterine leiomyoma, the control group - 45 healthy women. Gynaecological and obstetric history, hormone content in peripheral blood and pelvic vessels (estradiol, progesterone) were analysed. Statistical processing of clinical material was performed using Microsoft Excel, Statistica 7.0, and Statistica 8.0 for Windows. Results. The frequency of infertility in the surveyed women with LM was 18.9 %. One in three patients in the main group (33.3 %) did not give birth, which was statistically different from the healthy women group. In this case, 25.6 % of women in the main group did not use any methods of contraception. It was found that 51.11 % of patients with LM had threatened miscarriage in their history, 37.5 % – complicated delivery. Pathological changes in the concentrations of estradiol and progesterone in the preferential blood and blood vessels of women with fibroids have been identified. We have found that the content of sex hormones in the local bloodstream has a reliable relationship with the location of the myomatous node. Conclusion. The obtained results may indicate that leiomyoma contributes to the reduction of fertility. This is evidenced by the fact that women with LM are more likely to have the risk of miscarriage, complicated delivery and delivery by caesarean section, including complicated one. The findings have made a significant contribution to the further development of effective strategies for the prevention and treatment of infertility in women with fibrotic uterine lesions.

Publisher

OU Scientific Route

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Uterine fibroids and fertility: a modern view of the problem. A literature review;Journal of obstetrics and women's diseases;2022-04-15

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