Survey of cancer cell anatomy in nonadhesive confinement reveals a role for filamin-A and fascin-1 in leader bleb

Survey of cancer cell anatomy in nonadhesive confinement reveals a role for filamin-A and fascin-1 in leader bleb–based migration

Published:2021-08-19 Issue:18 Volume:32 Page:1772-1791
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Adams Gregory¹,López Magdalena Preciado¹,Cartagena-Rivera Alexander X.²,Waterman Clare M.¹

Affiliation:

1. Cell and Developmental Biology Center, National Heart, Lung and Blood Institute, and

2. Section on Mechanobiology, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892

Abstract

We analyzed the localization of fluorescently tagged organelle-specific markers and actin-associated proteins in human melanoma and osteosarcoma cells undergoing leader bleb-based migration (LBBM) in nonadhesive confinement. It is also found that filamin-A and fascin-1 are important regulators in LBBM.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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