Affiliation:
1. Department of Dermatology and Department of Cell Biology, Duke University, Durham, NC 27710
Abstract
Desmosomes are cell-cell adhesion structures that are required for the integrity of the skin and heart. Here, we have used a proteomics approach to identify novel desmosome-associated proteins. Ablation of Crk and Crkl, two such proteins identified, results in desmosome defects, epidermal fragility and neonatal lethality.
Publisher
American Society for Cell Biology (ASCB)
Subject
Cell Biology,Molecular Biology
Cited by
22 articles.
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