A role for keratins in supporting mitochondrial organization and function in skin keratinocytes-Reference-Cited by-同舟云学术

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes

Published:2020-05-15 Issue:11 Volume:31 Page:1103-1111
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Steen Kaylee¹,Chen Desu²,Wang Fengrong¹,Majumdar Ritankar³,Chen Song³,Kumar Surinder⁴,Lombard David B.⁴⁵,Weigert Roberto²,Zieman Abigail G.¹,Parent Carole A.¹³⁵,Coulombe Pierre A.¹⁶⁵

Affiliation:

1. Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109

2. Laboratory for Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

3. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109

4. Department of Pathology, University of Michigan, Ann Arbor, MI 48109

5. Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109

6. Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109

Abstract

We provide evidence that keratins (K) 6 and 16 modulate the organization, movement, and function of mitochondria in skin keratinocytes. Loss of either K6 or K16 protein results in reduced mitochondrial respiration and elevated reactive oxygen species. This newly defined role may be relevant to diseases caused by mutations in K6 or K16.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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