Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin-Reference-Cited by-同舟云学术

Abl signaling directs growth of a pioneer axon in Drosophila by shaping the intrinsic fluctuations of actin

Published:2020-03-15 Issue:6 Volume:31 Page:466-477
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Clarke Akanni¹²,McQueen Philip G.³,Fang Hsiao Yu¹,Kannan Ramakrishnan¹,Wang Victor³,McCreedy Evan³,Wincovitch Stephen⁴,Giniger Edward¹^ORCID

Affiliation:

1. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892

2. Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine/National Institutes of Health Graduate Partnerships Program, Washington, DC 20037

3. Center for Information Technology, National Institutes of Health, Bethesda, MD 20892

4. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892

Abstract

Live imaging reveals that a forward bias of the stochastic actin fluctuations in the distal part of an axon drives axon extension by advancing the protrusive, filopodial domain of the growth cone. The actin mass is itself shaped by guidance signaling via Abl tyrosine kinase, which regulates growth cone length and minimizes its disorder.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference39 articles.

1. Automated profiling of growth cone heterogeneity defines relations between morphology and motility

2. Enabled Negatively Regulates Diaphanous-Driven Actin Dynamics In Vitro and In Vivo

3. Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition

4. Notch Steers Drosophila ISNb Motor Axons by Regulating the Abl Signaling Pathway

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