Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone in<i>Drosophila</i>-Reference-Cited by-同舟云学术

Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone inDrosophila

Published:2023-07-01 Issue:8 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Fang Hsiao Yu¹,Forghani Rameen¹,Clarke Akanni¹,McQueen Philip G.¹,Chandrasekaran Aravind¹²,O’Neill Kate M.¹³,Losert Wolfgang³,Papoian Garegin A.²,Giniger Edward¹

Affiliation:

1. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892

2. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20752

3. Institute for Physical Sciences and Department of Physics, University of Maryland, College Park, MD 20752

Abstract

Live imaging in vivo is used to study the role of the actin polymerase Ena in axon growth. We find that Ena strongly regulates filopodial morphology despite having only modest effects on actin distribution. We suggest that the main role of Ena is keeping growth cone morphology stable in the face of the varying actin distribution that drives axon growth.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference57 articles.

1. Ena/VASP: towards resolving a pointed controversy at the barbed end

2. Negative Regulation of Fibroblast Motility by Ena/VASP Proteins

3. Enabled Negatively Regulates Diaphanous-Driven Actin Dynamics In Vitro and In Vivo

4. Cascade pathway of filopodia formation downstream of SCAR

5. Actin Dynamics, Architecture, and Mechanics in Cell Motility

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