GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis-Reference-Cited by-同舟云学术

GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis

Published:2015-03 Issue:5 Volume:26 Page:874-886
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Xu Xuehua¹,Gera Nidhi¹,Li Hongyan¹²,Yun Michelle¹,Zhang Liyong³,Wang Youhong¹,Wang Q. Jane³,Jin Tian¹

Affiliation:

1. Chemotaxis Signaling Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852

2. Center of Therapeutic Research for Hepatocellular Carcinoma, 302 Hospital of PLA, Beijing 100039, China

3. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213

Abstract

A novel signaling pathway consisting of Gai, PLC, PKCβ, PKD, SSH2, and cofilin is crucial for GPCR-mediated chemotaxis in neutrophils. This pathway regulates depolymerization of the actin network that drives the directional migration of neutrophils.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference37 articles.

1. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

2. Protein kinase C isoforms in normal and leukemic neutrophils: altered levels in leukemic neutrophils and changes during myeloid maturation in chronic myeloid leukemia

3. Phosphorylation of Ser 402 impedes phosphatase activity of slingshot 1

4. Protein Kinase C Isoforms in Neutrophil Adhesion and Activation

5. Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family

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