Affiliation:
1. Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, California 91125
Abstract
Ovulation in Caenorhabditis elegans requires inositol 1,4,5-triphosphate (IP3) signaling activated by the epidermal growth factor (EGF)-receptor homolog LET-23. We generated a deletion mutant of a type I 5-phosphatase,ipp-5, and found a novel ovulation phenotype whereby the spermatheca hyperextends to engulf two oocytes per ovulation cycle. The temporal and spatial expression of IPP-5 is consistent with its proposed inhibition of IP3signaling in the adult spermatheca. ipp-5 acts downstream oflet-23, and interacts withlet-23–mediated IP3signaling pathway genes. We infer that IPP-5 negatively regulates IP3signaling to ensure proper spermathecal contraction.
Publisher
American Society for Cell Biology (ASCB)
Subject
Cell Biology,Molecular Biology
Cited by
68 articles.
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