Redox signaling modulates Rho activity and tissue contractility in theCaenorhabditis elegansspermatheca-Reference-Cited by-同舟云学术

Redox signaling modulates Rho activity and tissue contractility in theCaenorhabditis elegansspermatheca

Published:2020-07-01 Issue:14 Volume:31 Page:1486-1497
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Kelley Charlotte A.¹,De Henau Sasha²,Bell Liam¹,Dansen Tobias B.²,Cram Erin J.¹

Affiliation:

1. Department of Biology, Northeastern University, Boston, MA 02115

2. Center for Molecular Medicine, Molecular Cancer Research Section, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands

Abstract

H2O2modulates RHO-1/Rho activity in the contractile tissue of the C. elegans spermatheca. Both exogenous and endogenously generated H2O2decrease spermathecal contractility by inhibition of RHO-1 through oxidation of Cys 20. Regulation of H2O2levels in the spermatheca depends on the activity of the cytosolic superoxide dismutase SOD-1.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference93 articles.

1. Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif

2. In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis

3. Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

4. Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3

5. Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments

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