Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch-Reference-Cited by-同舟云学术

Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch

Published:2021-08-19 Issue:18 Volume:32 Page:1724-1736
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Miroshnikova Yekaterina A.¹²³⁴⁵,Manet Sandra¹²³,Li Xinping⁴,Wickström Sara A.⁴⁵⁶⁷,Faurobert Eva¹²³,Albiges-Rizo Corinne¹²³

Affiliation:

1. Université Grenoble Alpes, Institute for Advanced Biosciences, Grenoble 38042, France

2. INSERM U1209, Institute for Advanced Biosciences, F-38700 La Tronche, France

3. CNRS UMR 5039, Institute for Advanced Biosciences, F-38700 La Tronche, France

4. Max Planck Institute for Biology of Ageing, D-50931 Cologne, Germany

5. Helsinki Institute of Life Science, University of Helsinki, FI-00014 Helsinki, Finland

6. Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland

7. Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, FI-00014 Helsinki, Finland

Abstract

Mechanical forces are key stimuli that dynamically adjust vessel distribution and diameter, but the precise mechanisms of force adaptation are unclear. This study identifies a biphasic response to cyclic stretch, consisting of an initial calcium-driven junctional mechanoresponse followed by mechanoadaptation facilitated by monolayer stiffening.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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