Affiliation:
1. Department of Pharmacology and Toxicology and
2. Service of Cardiology, University of Lausanne, Switzerland
Abstract
Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several channels bearing PY motifs, whereas endoplasmic reticulum-associated degradation (involving ubiquitylation) plays an important role in the biogenesis of normal and defective channels.
Publisher
American Physiological Society
Cited by
88 articles.
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