Trisomy 21 increases microtubules and disrupts centriolar satellite localization-Reference-Cited by-同舟云学术

Trisomy 21 increases microtubules and disrupts centriolar satellite localization

Published:2022-07-01 Issue:8 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

McCurdy Bailey L.¹,Jewett Cayla E.¹²,Stemm-Wolf Alexander J.¹,Duc Huy Nguyen³,Joshi Molishree³,Espinosa Joaquin M.²³⁴,Prekeris Rytis¹,Pearson Chad G.¹²

Affiliation:

1. Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045-2537

2. Linda Crnic Institute for Down Syndrome, University of Colorado School of Medicine, Aurora, CO 80045-2537

3. Functional Genomics Facility, University of Colorado School of Medicine, Aurora, CO 80045-2537

4. Department of Pharmacology, University of Colorado School of Medicine, University of Colorado School of Medicine, Aurora, CO 80045-2537

Abstract

This article explores why elevated pericentrin in trisomy 21 negatively impacts primary cilia. It is found that elevated pericentrin produces more pericentrosomal puncta that associate with and increase microtubules. Elevated pericentrin and microtubules mislocalize centriolar satellites in a pericentrosomal crowd.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference55 articles.

1. Centrosomes and cilia in human disease

2. Centrosome composition and microtubule anchoring mechanisms

3. Origin and Evolution of the Centrosome

4. Mechanism and Regulation of Centriole and Cilium Biogenesis

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Host-derived protein profiles of human neonatal meconium across gestational ages;Nature Communications;2024-07-17

2. Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes;The FEBS Journal;2024-06-02

3. Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration;EMBO reports;2023-11-16

4. Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome;Disease Models & Mechanisms;2023-04-01

5. Circadian oscillation in primary cilium length by clock genes regulate fibroblast cell migration;2023-01-24