Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins-Reference-Cited by-同舟云学术

Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins

Published:2018-02 Issue:3 Volume:29 Page:326-338
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Burgos-Bravo Francesca¹²,Figueroa Nataniel L.³,Casanova-Morales Nathalie⁴,Quest Andrew F. G.¹²,Wilson Christian A. M.⁴,Leyton Lisette¹²

Affiliation:

1. Cellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453 Santiago, Chile

2. Advanced Center for Chronic Diseases (ACCDiS), Center for Studies of Exercise, Metabolism and Cancer, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453 Santiago, Chile

3. Physics Department, Pontificia Universidad Católica de Chile, 782-0436 Santiago, Chile

4. Biochemistry and Molecular Biology Department, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 838-0494 Santiago, Chile

Abstract

Single-molecule measurements combined with a novel mathematical strategy were applied to accurately characterize how bimolecular interactions respond to mechanical force, especially when protein purification is not possible. Specifically, we studied the effect of force on Thy-1/αvβ3 integrin interaction, a mediator of neuron-astrocyte communication.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference75 articles.

1. AFM measurements of interactions between the platelet integrin receptor GPIIbIIIa and fibrinogen

2. Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration

3. The Forces Behind Cell Movement

4. Optical trapping and manipulation of neutral particles using lasers

Cited by 25 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The study on 4D culture system of squamous cell carcinoma of tongue;Biomedical Materials;2024-09-10

2. Characterization of the interaction between the Sec61 translocon complex and ppαF using optical tweezers;Protein Science;2024-05-15

3. Bioinformatics, thermodynamics, and mechanical resistance of the FtsZ-ZipA complex of Escherichia coli supports a highly dynamic protein interaction in the divisome;Biochimica et Biophysica Acta (BBA) - General Subjects;2023-12

4. Thy-1 (CD90)-regulated cell adhesion and migration of mesenchymal cells: insights into adhesomes, mechanical forces, and signaling pathways;Frontiers in Cell and Developmental Biology;2023-11-30

5. Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson’s Disease;International Journal of Molecular Sciences;2023-04-25