Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins-Reference-Cited by-同舟云学术

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

Published:2018-01-15 Issue:2 Volume:29 Page:220-233
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Stephens Andrew D.¹,Liu Patrick Z.¹,Banigan Edward J.²³,Almassalha Luay M.⁴,Backman Vadim⁴,Adam Stephen A.⁵,Goldman Robert D.⁵,Marko John F.¹²

Affiliation:

1. Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208

2. Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208

3. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139

4. Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208

5. Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611

Abstract

Chromatin decompaction via increasing euchromatin or decreasing heterochromatin results in a softer nucleus and abnormal nuclear blebbing, independent of lamin perturbations. Conversely, increasing heterochromatin stiffens the nucleus and rescues nuclear morphology in lamin-perturbed cells that present abnormal nuclear morphology.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference62 articles.

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3. Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

4. Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force

5. Nuclear lamin functions and disease

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