FOXO nuclear shuttling dynamics are stimulus-dependent and correspond with cell fate-Reference-Cited by-同舟云学术

FOXO nuclear shuttling dynamics are stimulus-dependent and correspond with cell fate

Published:2023-03-01 Issue:3 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Lasick Kathleen A.¹,Jose Elizabeth¹,Samayoa Allison M.²,Shanks Lisa¹,Pond Kelvin W.¹³⁴,Thorne Curtis A.³⁴,Paek Andrew L.¹⁴^ORCID

Affiliation:

1. Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721

2. Cancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ 85719

3. Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85721

4. University of Arizona Cancer Center, Tucson, AZ 85724

Abstract

Both H2O2 and serum starvation activate FOXO transcription factors, but they lead to different FOXO-induced cell outcomes. Here we find a link between the dynamics of FOXO activation and cell fate. H2O2 induces sustained nuclear FOXO, which is linked to cell death, while serum starvation causes pulses of nuclear FOXO and cell-cycle arrest.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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