PUMA and BIM Are Required for Oncogene Inactivation–Induced Apoptosis

Author:

Bean Gregory R.12,Ganesan Yogesh Tengarai1,Dong Yiyu1,Takeda Shugaku1,Liu Han1,Chan Po M.1,Huang Yafen1,Chodosh Lewis A.3,Zambetti Gerard P.4,Hsieh James J.-D.15,Cheng Emily H.-Y.167

Affiliation:

1. Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

2. Division of Biology & Biomedical Sciences, Washington University, St. Louis, MO 63110, USA.

3. Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

4. St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

5. Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

6. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

7. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

Abstract

Combining drugs that inhibit antiapoptotic proteins with oncogenic kinase inhibitors may overcome drug resistance in cancer therapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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