Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Author:

Letai Anthony,Bassik Michael C.,Walensky Loren D.,Sorcinelli Mia D.,Weiler Solly,Korsmeyer Stanley J.

Publisher

Elsevier BV

Subject

Cancer Research,Cell Biology,Oncology

Reference37 articles.

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2. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins;Boyd;Oncogene,1995

3. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis;Cheng;Mol. Cell,2001

4. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions;Chittenden;EMBO J.,1995

5. Regulation of apoptosis by BH3 domains in a cell-free system;Cosulich;Curr. Biol.,1997

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