Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators-Reference-Cited by-同舟云学术

Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators

Published:2022-10-01 Issue:12 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Tan Tan¹²,Wu Chuanfen¹,Liu Boye³,Pan Bih-Fang⁴,Hawke David H.⁴,Su Zehao⁵,Liu Shuaishuai⁵,Zhang Wei⁵,Wang Ruoning¹,Lin Sue-Hwa⁶,Kuang Jian¹

Affiliation:

1. Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030

2. Department of Biochemistry and Molecular Biology, Hengyang Medical School, The University of South China, Hengyang, Hunan 421001, China

3. Key Laboratory for Biodiversity and Ecological Engineering of Ministry of Education

4. Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030

5. Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China

6. Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030

Abstract

The work in this paper demonstrates that the substantial increase in the apparent molecular weight of Cdc25C, Myt1, Wee1, Greawall, and APC3 during M-phase induction are each due to simultaneous phosphorylation of a considerable portion of S/T/Y residues in a long intrinsically disordered region that is enriched in both S/T residues and S/TP motifs.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference125 articles.

1. The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II

2. Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

3. Cloning and Characterization of Xenopus Rsk2, the Predominant p90 Rsk Isozyme in Oocytes and Eggs

4. Determinants for Activation of the Atypical AGC Kinase Greatwall during M Phase Entry

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