Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling-Reference-Cited by-同舟云学术

Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

Published:2011-06-28 Issue:179 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Alexander Jes¹,Lim Daniel¹,Joughin Brian A.¹,Hegemann Björn²,Hutchins James R. A.²,Ehrenberger Tobias¹,Ivins Frank³,Sessa Fabio⁴,Hudecz Otto²,Nigg Erich A.⁵,Fry Andrew M.⁶,Musacchio Andrea⁴,Stukenberg P. Todd⁷,Mechtler Karl²,Peters Jan-Michael²,Smerdon Stephen J.³,Yaffe Michael B.¹⁸

Affiliation:

1. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.

3. Division of Molecular Structure, Medical Research Council National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.

4. Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20139 Milan, Italy.

5. Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.

6. Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.

7. Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

8. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Mitotic kinases that localize to the same compartment show negative selectivity for residues in each other’s recognition motifs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference125 articles.

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2. Mechanisms of specificity in protein phosphorylation

3. Systematic Discovery of In Vivo Phosphorylation Networks

4. B. Alberts Molecular Biology of the Cell (Garland Science New York 2002) pp. 1027–1062.

5. The cellular geography of Aurora kinases

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