The short-chain fatty acid acetate modulates epithelial-to-mesenchymal transition-Reference-Cited by-同舟云学术

The short-chain fatty acid acetate modulates epithelial-to-mesenchymal transition

Published:2022-07-01 Issue:8 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Lyu Junfang¹²,Pirooznia Mehdi³,Li Yuesheng³,Xiong Jianhua¹²

Affiliation:

1. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, St. Petersburg, FL 33701

2. Institute for Fundamental Biomedical Research, Johns Hopkins All Children’s Hospital, St. Petersburg, FL 33701

3. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892

Abstract

Epithelial-to-mesenchymal transition (EMT) has been linked to various human diseases including cancer. The underlying metabolic regulators, however, remain poorly understood. Here we show how the short-chain fatty acid acetate restrains EMT. Our findings indicate that acetate is a potent metabolic regulator of EMT.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference54 articles.

1. Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis

2. Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

3. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species

4. G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells

5. Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

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