In vivo imaging reveals independent intraflagellar transport of the nexin–dynein regulatory complex subunits DRC2 and DRC4-Reference-Cited by-同舟云学术

In vivo imaging reveals independent intraflagellar transport of the nexin–dynein regulatory complex subunits DRC2 and DRC4

Published:2023-02-01 Issue:2 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Saravanan Sahana¹,Trischler Douglas²,Bower Raqual²,Porter Mary²,Lechtreck Karl¹^ORCID

Affiliation:

1. Department of Cellular Biology, University of Georgia, Athens, GA 30602

2. Department of Genetics, Cell Biology, and Development, University of Minnesota Medical School, Minneapolis, MN 55455

Abstract

The core nexin–dynein regulatory complex (N-DRC) proteins DRC2 and DRC4 enter flagella independently of each other by IFT. This indicates that the N-DRC assembles in a stepwise process by the addition of subunits to the axoneme rather than by delivery of a preassembled precursor complex.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference55 articles.

1. ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery

2. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia

3. Nephrocystin-4 controls ciliary trafficking of membrane and large soluble proteins at the transition zone

4. DRC2/CCDC65 is a central hub for assembly of the nexin–dynein regulatory complex and other regulators of ciliary and flagellar motility

5. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Extensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport;Cell;2024-08

2. Development of functional spermatozoa in mammalian spermiogenesis;Development;2024-07-15

3. Distribution and bulk flow analyses of the intraflagellar transport (IFT) motor kinesin‐2 support an “on‐demand” model for Chlamydomonas ciliary length control;Cytoskeleton;2024-03-08

4. Assembly of FAP93 at the proximal axoneme in Chlamydomonas cilia;Cytoskeleton;2024-01-15

5. Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism;Nature Communications;2023-09-15