DRC2/CCDC65 is a central hub for assembly of the nexin–dynein regulatory complex and other regulators of ciliary and flagellar motility-Reference-Cited by-同舟云学术

DRC2/CCDC65 is a central hub for assembly of the nexin–dynein regulatory complex and other regulators of ciliary and flagellar motility

Published:2018-01-15 Issue:2 Volume:29 Page:137-153
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Bower Raqual¹,Tritschler Douglas¹,Mills Kristyn VanderWaal¹,Heuser Thomas²³,Nicastro Daniela²⁴,Porter Mary E.¹

Affiliation:

1. Department of Genetics, Cell Biology, and Development, University of Minnesota Medical School, Minneapolis, MN 55455

2. Biology Department and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454

3. Vienna Biocenter Core Facilities, 1030 Vienna, Austria

4. Departments of Cell Biology and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390

Abstract

DRC2 is a subunit of the nexin–dynein regulatory complex linked to primary ciliary dyskinesia. Little is known about the impact of drc2 mutations on axoneme composition and structure. We used proteomic and structural approaches to reveal that DRC2 coassembles with DRC1 to attach the N-DRC to the A-tubule and mediate interactions with other regulatory structures.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference91 articles.

1. The nexin link and B-tubule glutamylation maintain the alignment of outer doublets in the ciliary axoneme

2. The Genome of the Diatom Thalassiosira Pseudonana : Ecology, Evolution, and Metabolism

3. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia

4. DRC3 connects the N-DRC to dynein g to regulate flagellar waveform

5. Quantitative Proteomic Analysis of Human Airway Cilia Identifies Previously Uncharacterized Proteins of High Abundance

Cited by 44 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The MBO2/FAP58 heterodimer stabilizes assembly of inner arm dynein b and reveals axoneme asymmetries involved in ciliary waveform;Molecular Biology of the Cell;2024-05-01

2. Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy;2024-03-21

3. Assembly of FAP93 at the proximal axoneme in Chlamydomonas cilia;Cytoskeleton;2024-01-15

4. Effects of Tcte1 knockout on energy chain transportation and spermatogenesis: implications for male infertility;Human Reproduction Open;2024-01-01

5. CCDC65, encoding a component of the axonemal Nexin‐Dynein regulatory complex, is required for sperm flagellum structure in humans;Clinical Genetics;2023-11-17