Junctional integrity and directional mobility of lymphatic endothelial cell monolayers are disrupted by saturated fatty acids-Reference-Cited by-同舟云学术

Junctional integrity and directional mobility of lymphatic endothelial cell monolayers are disrupted by saturated fatty acids

Published:2023-04-01 Issue:4 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Tokarz Victoria L.¹²,Pereira Rafaela V. S.¹,Jaldin-Fincati Javier R.¹,Mylvaganam Sivakami¹³,Klip Amira¹²³⁴

Affiliation:

1. Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada

2. Department of Physiology, University of Toronto, Toronto, ON M5S 1A1, Canada

3. Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A1, Canada

4. Department of Paediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada

Abstract

Obesity impairs lymphatic function, but the contribution of lymphatic endothelial cells to metabolic disease phenotypes is poorly understood. It is shown that the saturated fatty acid palmitate, but not the unsaturated fatty acid palmitoleate, causes ROCK-dependent reorganization of the actin cytoskeleton that detaches it from adherens junction proteins and impairs directional migration.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference80 articles.

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