The mitochondrial RNA granule modulates manganese-dependent cell toxicity-Reference-Cited by-同舟云学术

The mitochondrial RNA granule modulates manganese-dependent cell toxicity

Published:2022-10-01 Issue:12 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Werner E.¹^ORCID,Gokhale A.¹^ORCID,Ackert M.²,Xu C.³,Wen Z.³,Roberts A. M.⁴,Roberts B. R.⁴,Vrailas-Mortimer A.²,Crocker A.⁵,Faundez V.¹^ORCID

Affiliation:

1. Department of Cell Biology, Emory University, Atlanta, GA 30322

2. School of Biological Sciences, Illinois State University, Normal, IL 617901

3. Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322

4. Department of Biochemistry, Emory University, Atlanta, GA 30322

5. Program in Neuroscience, Middlebury College, Middlebury, VT 05753

Abstract

SLC30A10 and PARK2 mutations compromise the mitochondrial RNA granule, which is required for processing polycistronic mitochondrial RNAs. Cells and Drosophila lacking RNA granule components were resistant to manganese. It is concluded that the down-regulation of the granule function is an adaptive mechanism for cells exposed to manganese.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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