Insights into the cellular mechanism of the yeast ubiquitin ligase APC/C-Cdh1 from the analysis of in vivo degrons-Reference-Cited by-同舟云学术

Insights into the cellular mechanism of the yeast ubiquitin ligase APC/C-Cdh1 from the analysis of in vivo degrons

Published:2015-03 Issue:5 Volume:26 Page:843-858
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Arnold Lea¹,Höckner Sebastian¹,Seufert Wolfgang¹

Affiliation:

1. Department of Genetics, University of Regensburg, D-93040 Regensburg, Germany

Abstract

In vivo analysis in budding yeast identifies APC/C-Cdh1–specific minimal degrons carrying either a D or a KEN box and a nuclear localization sequence. APC/C-Cdh1 activity is restricted to the nucleus, maximal in the nucleoplasm, and absent from the cytoplasm, allowing for spatiotemporal control of Cdh1 substrate proteolysis.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference66 articles.

1. Regulation of APC/C-Cdh1 and Its Function in Neuronal Survival

2. Structural insights into anaphase-promoting complex function and mechanism

4. Hsl1p, a Swe1p Inhibitor, Is Degraded via the Anaphase-Promoting Complex

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